Interleukin-10 deficiency exacerbates inflammation-induced tau pathology

Abstract Background The presence of hyperphosphorylated microtubule-associated protein tau is strongly correlated with cognitive decline and neuroinflammation in Alzheimer’s disease and related tauopathies. However, the role of inflammation and anti-inflammatory interventions in tauopathies is uncle...

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Bibliographic Details
Main Authors: Lea L. Weston, Shanya Jiang, Devon Chisholm, Lauren L. Jantzie, Kiran Bhaskar
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Neuroinflammation
Subjects:
Tau
Online Access:https://doi.org/10.1186/s12974-021-02211-1