Desferrioxamine Supports Metabolic Function in Primary Human Macrophages Infected With Mycobacterium tuberculosis

Desferrioxamine Supports Metabolic Function in Primary Human Macrophages Infected With Mycobacterium tuberculosis

Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis continues to rise. Consequently, research is now focused on the development of th...

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Bibliographic Details
Main Authors: James Joseph Phelan, Kate McQuaid, Colin Kenny, Karl Michael Gogan, Dónal J. Cox, Sharee Ann Basdeo, Seónadh O’Leary, Simone Christa Tazoll, Cilian Ó Maoldomhnaigh, Mary P. O’Sullivan, Luke A. O’Neill, Maureen J. O’Sullivan, Joseph Keane
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
glycolysis
immunometabolism
Warburg effect
tuberculosis
iron chelation
iron metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00836/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00836/full

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