LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Abstract Background The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-associated immune remodeling and leukemia pathogenesis. Aged HSCs show changes to their epigenome, such as alterations in DNA methylation and histone methylation and acetylation landscapes. We p...

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Bibliographic Details
Main Authors: Ani Grigoryan, Novella Guidi, Katharina Senger, Thomas Liehr, Karin Soller, Gina Marka, Angelika Vollmer, Yolanda Markaki, Heinrich Leonhardt, Christian Buske, Daniel B. Lipka, Christoph Plass, Yi Zheng, Medhanie A. Mulaw, Hartmut Geiger, Maria Carolina Florian
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Genome Biology
Subjects:
Hematopoietic stem cell (HSC)
Aging
Chromatin architecture
LaminA/C
Chromosome 11
Online Access:http://link.springer.com/article/10.1186/s13059-018-1557-3

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http://link.springer.com/article/10.1186/s13059-018-1557-3

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