Human Chromosome 18 and Acrocentrics: A Dangerous Liaison

Human Chromosome 18 and Acrocentrics: A Dangerous Liaison

The presence of thousands of repetitive sequences makes the centromere a fragile region subject to breakage. In this study we collected 31 cases of rearrangements of chromosome 18, of which 16 involved an acrocentric chromosome, during genetic screening done in three centers. We noticed a significan...

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Bibliographic Details
Main Authors: Nicoletta Villa, Serena Redaelli, Elena Sala, Donatella Conconi, Lorenza Romitti, Emanuela Manfredini, Francesca Crosti, Gaia Roversi, Marialuisa Lavitrano, Ornella Rodeschini, Maria Paola Recalcati, Rocco Piazza, Leda Dalprà, Paola Riva, Angela Bentivegna
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
acrocentric chromosomes
chromosome 18
centromeric/pericentromeric regions
chromosome translocations
chromosome territory
nuclear subcompartments
Online Access:https://www.mdpi.com/1422-0067/22/11/5637

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https://www.mdpi.com/1422-0067/22/11/5637

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