Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens

Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens

Human fetal midbrain tissue grafting has provided proof-of-concept for dopamine cell replacement therapy (CRT) in Parkinson's disease (PD). However, limited tissue availability has hindered the development and widespread use of this experimental therapy. Here we present a method for generating...

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Bibliographic Details
Main Authors: Diogo Ribeiro, Rocio Laguna Goya, Geeta Ravindran, Romina Vuono, Clare L. Parish, Claire Foldi, Tobias Piroth, Shanzheng Yang, Malin Parmar, Guido Nikkhah, Jens Hjerling-Leffler, Olle Lindvall, Roger A. Barker, Ernest Arenas
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Neurobiology of Disease
Subjects:
Dopaminergic
Human fetal ventral midbrain
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002938

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http://www.sciencedirect.com/science/article/pii/S0969996112002938

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