Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

Protein misfolding is implicated in numerous lethal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). There are no therapies that reverse these protein-misfolding events. We aim to apply Hsp104, a hexameric AAA+ protein from yeast, to target misfo...

Full description

Bibliographic Details
Main Authors: Meredith E. Jackrel, James Shorter
Format: Article
Language:English
Published: The Company of Biologists 2014-10-01
Series:Disease Models & Mechanisms
Subjects:
FUS
Hsp104
TDP-43
α-synuclein
Disaggregase
Neurodegeneration
Online Access:http://dmm.biologists.org/content/7/10/1175

Internet

http://dmm.biologists.org/content/7/10/1175

Similar Items