Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

Ben C Creelan,1 Dmitry I Gabrilovich,2 Jhanelle E Gray,1 Charles C Williams,1 Tawee Tanvetyanon,1 Eric B Haura,1 Jeffrey S Weber,3 Geoffrey T Gibney,4 Joseph Markowitz,5 Joel W Proksch,6 Scott A Reisman,6 Mark D McKee,7 Melanie P Chin,6 Colin J Meyer,6 Scott J Antonia11Department of Thoracic Oncolog...

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Bibliographic Details
Main Authors: Creelan BC, Gabrilovich DI, Gray JE, Williams CC, Tanvetyanon T, Haura EB, Weber JS, Gibney GT, Markowitz J, Proksch JW, Reisman SA, McKee MD, Chin MP, Meyer CJ, Antonia SJ
Format: Article
Language:English
Published: Dove Medical Press 2017-08-01
Series:OncoTargets and Therapy
Subjects:
Antioxidant inflammation modulator
Nitrotyrosine
Nitric oxide synthase
Melanoma
Non-small cell lung cancer
Immuno-Oncology
Myeloid-derived suppressor cells
Bardoxolone methyl
Online Access:https://www.dovepress.com/safety-pharmacokinetics-and-pharmacodynamics-of-oral-omaveloxolone-rta-peer-reviewed-article-OTT

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https://www.dovepress.com/safety-pharmacokinetics-and-pharmacodynamics-of-oral-omaveloxolone-rta-peer-reviewed-article-OTT

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