SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causing alterations over downstream changes secondary to t...

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Main Authors: Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
C9ORF72-repeat expansions
Pre-clinical models
Transcriptome
Genome-wide mechanisms of neuroprotection
SRSF1-dependent RNA nuclear export
Online Access:https://doi.org/10.1186/s13024-021-00475-y

Internet

https://doi.org/10.1186/s13024-021-00475-y

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