Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy.

Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy.

In mice, the calcium-dependent phosphatase calcineurin A (CnA) induces a transcriptional pathway leading to pathological cardiac hypertrophy. Interestingly, induction of CnA has been frequently noticed in human hypertrophic and failing hearts. Independently, the arrhythmia vulnerability of such hear...

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Bibliographic Details
Main Authors: Magda S C Fontes, Antonia J A Raaijmakers, Tessa van Doorn, Bart Kok, Sylvia Nieuwenhuis, Roel van der Nagel, Marc A Vos, Teun P de Boer, Harold V M van Rijen, Marti F A Bierhuizen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3909068?pdf=render

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http://europepmc.org/articles/PMC3909068?pdf=render

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