Elucidating Sources and Roles of Granzymes A and B during Bacterial Infection and Sepsis

Elucidating Sources and Roles of Granzymes A and B during Bacterial Infection and Sepsis

During bacterial sepsis, proinflammatory cytokines contribute to multiorgan failure and death in a process regulated in part by cytolytic cell granzymes. When challenged with a sublethal dose of the identified mouse pathogen Brucella microti, wild-type (WT) and granzyme A (gzmA)−/− mice eliminate th...

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Bibliographic Details
Main Authors: Maykel A. Arias, María P. Jiménez de Bagües, Nacho Aguiló, Sebastián Menao, Sandra Hervás-Stubbs, Alba de Martino, Ana Alcaraz, Markus M. Simon, Christopher J. Froelich, Julián Pardo
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400480X

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http://www.sciencedirect.com/science/article/pii/S221112471400480X

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