Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia. Due to high sequence homology, selective targeting of any of the M1-M5 mAChRs through the endogenous ligand binding site has b...

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Bibliographic Details
Main Authors: Emma T. van der Westhuizen, K. H. Christopher Choy, Celine Valant, Simon McKenzie-Nickson, Sophie J. Bradley, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
muscarinic receptor
allosteric modulation
Alzheimer’s disease
schizophrenia
biased agonism
biased allostery
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.606656/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.606656/full

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