The Cutting Edge: The Role of mTOR Signaling in Laminopathies

The Cutting Edge: The Role of mTOR Signaling in Laminopathies

The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase that regulates anabolic and catabolic processes, in response to environmental inputs. The existence of mTOR in numerous cell compartments explains its specific ability to sense stress, execute growth signals, and regu...

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Bibliographic Details
Main Authors: Francesca Chiarini, Camilla Evangelisti, Vittoria Cenni, Antonietta Fazio, Francesca Paganelli, Alberto M. Martelli, Giovanna Lattanzi
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
mTOR
laminopathies
lamin A/C
Emery-Dreifuss muscular dystrophy (EDMD)
Hutchinson-Gilford progeria syndrome (HGPS)
autophagy
cellular signaling
metabolism
bone remodeling
ageing
Online Access:https://www.mdpi.com/1422-0067/20/4/847

Internet

https://www.mdpi.com/1422-0067/20/4/847

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