An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism

Objective: Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle are limited. Therefore, the present study aimed...

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Bibliographic Details
Main Authors: Dennis Dahlmans, Alexandre Houzelle, Pénélope Andreux, Johanna A. Jörgensen, Xu Wang, Leon J. de Windt, Patrick Schrauwen, Johan Auwerx, Joris Hoeks
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Molecular Metabolism
Subjects:
Skeletal muscle metabolism
Mitochondria
MicroRNA
Screening
Type 2 diabetes
Oxidative capacity
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817303125

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http://www.sciencedirect.com/science/article/pii/S2212877817303125

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