Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity

Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity

α-Synuclein (α-Syn) is intimately linked to the etiology of Parkinson's Disease, as mutations and even subtle increases in gene dosage result in early onset of the disease. However, how this protein causes neuronal dysfunction and neurodegeneration is incompletely understood. We thus examined a...

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Bibliographic Details
Main Authors: Johan Tolö, Grit Taschenberger, Kristian Leite, Markus A. Stahlberg, Gesche Spehlbrink, Janina Kues, Francesca Munari, Stefano Capaldi, Stefan Becker, Markus Zweckstetter, Camin Dean, Mathias Bähr, Sebastian Kügler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
synuclein
ATP
calcium
reactive oxygen species
thiol oxidation
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00049/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00049/full

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