Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL

Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL

Deregulated Notch signaling has been extensively linked to T-cell acute lymphoblastic leukemia (T-ALL). Here, we show a direct relationship between Notch3 receptor and Jagged1 ligand in human cell lines and in a mouse model of T-ALL. We provide evidence that Notch-specific ligand Jagged1 is a new N...

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Bibliographic Details
Main Authors: Maria Pelullo, Roberta Quaranta, Claudio Talora, Saula Checquolo, Samantha Cialfi, Maria Pia Felli, Geertruy te Kronnie, Chiara Borga, Zein Mersini Besharat, Rocco Palermo, Lucia Di Marcotullio, Anthony J. Capobianco, Alberto Gulino, Isabella Screpanti, Diana Bellavia
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558614001602

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http://www.sciencedirect.com/science/article/pii/S1476558614001602

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