HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity

HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity

Background/Aims: For applicability of cell-based therapies aimed at the treatment of liver failure, such as bioartificial livers (BALs) and hepatocyte transplantation, it is essential that the applied hepatocytes tolerate exposure to the patient plasma. However, plasma from both healthy donors and a...

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Bibliographic Details
Main Authors: Martien van Wenum, Philipp Treskes, Aziza A.A. Adam, Vincent. A van der Mark, Aldo Jongejan, Perry D. Moerland, Thomas M. van Gulik, Ronald P.J. Oude Elferink, Robert A.F.M. Chamuleau, Ruurdtje Hoekstra
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Liver failure
Bioartifcial liver
Dedifferentiation
3D culture
Plasma toxicity
HepaRG
Online Access:https://www.karger.com/Article/FullText/492560

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https://www.karger.com/Article/FullText/492560

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