Optimized pharmacological control over the AAV-Gene-Switch vector for regulable gene therapy

Gene therapy in its current design is an irreversible process. It cannot be stopped in case of unwanted side effects, nor can expression levels of therapeutics be adjusted to individual patient’s needs. Thus, the Gene-Switch (GS) system for pharmacologically regulable neurotrophic factor expression...

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Bibliographic Details
Main Authors: Shi Cheng, Marcel M. van Gaalen, Mathias Bähr, Enrique Garea-Rodriguez, Sebastian Kügler
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001248