Oligomeric Aβ<sub>1-42</sub> Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function

Oligomeric Aβ<sub>1-42</sub> Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function

Alzheimer’s disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina with increasing age and in eyes of age-related macular degeneration (AMD) patients. To study Aβ-induced retinopathy, wild-type mice were injected with nanomolar human oligomeric Aβ<sub>1-42</sub>, wh...

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Bibliographic Details
Main Authors: Savannah A. Lynn, David A. Johnston, Jenny A. Scott, Rosie Munday, Roshni S. Desai, Eloise Keeling, Ruaridh Weaterton, Alexander Simpson, Dillon Davis, Thomas Freeman, David S. Chatelet, Anton Page, Angela J. Cree, Helena Lee, Tracey A. Newman, Andrew J. Lotery, J. Arjuna Ratnayaka
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
retinal pigment epithelium (RPE)
amyloid beta (Aβ)
age-related macular degeneration (AMD)
aging
autophagy–lysosomal pathway
sight loss
Online Access:https://www.mdpi.com/2073-4409/10/2/413

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https://www.mdpi.com/2073-4409/10/2/413

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