Transcriptomic Basis of Serum Resistance and Virulence Related Traits in XDR P. aeruginosa Evolved Under Antibiotic Pressure in a Morbidostat Device

Transcriptomic Basis of Serum Resistance and Virulence Related Traits in XDR P. aeruginosa Evolved Under Antibiotic Pressure in a Morbidostat Device

Colistin is a last resort antibiotic against the critical status pathogen Pseudomonas aeruginosa. Virulence and related traits such as biofilm formation and serum resistance after exposure to sub-inhibitory levels of colistin have been underexplored. We cultivated P. aeruginosa in a semi-automated m...

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Bibliographic Details
Main Authors: Mumina Javed, Benedikt Jentzsch, Maximilian Heinrich, Viola Ueltzhoeffer, Silke Peter, Ulrich Schoppmeier, Angel Angelov, Sandra Schwarz, Matthias Willmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Microbiology
Subjects:
multi-drug resistance
biofilm formation
evolutionary trajectories
serum susceptibility
colistin
combination drug therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.619542/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.619542/full

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