Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course
Analyses of IGHV gene mutations in chronic lymphocytic leukemia (CLL) have had a major impact on the prognostication and treatment of this disease. A hallmark of IGHV-mutation status is that it very rarely changes clonally over time. Nevertheless, targeted and deep DNA sequencing of IGHV-IGHD-IGHJ r...
Main Authors: | Davide Bagnara, Catherine Tang, Jennifer R. Brown, Siddha Kasar, Stacey Fernandes, Monica Colombo, Stefano Vergani, Andrea N. Mazzarello, Fabio Ghiotto, Silvia Bruno, Fortunato Morabito, Kanti R. Rai, Jonathan E. Kolitz, Jacqueline C. Barrientos, Steven L. Allen, Franco Fais, Matthew D. Scharff, Thomas MacCarthy, Nicholas Chiorazzi |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-05-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.640731/full |
Similar Items
-
Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?
by: Paola Monti, et al.
Published: (2020-10-01) -
A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice
by: Piers E. M. Patten, et al.
Published: (2021-03-01) -
AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression
by: Pablo Oppezzo, et al.
Published: (2021-05-01) -
Somatic evolutionary timings of driver mutations
by: Karen Gomez, et al.
Published: (2018-01-01) -
SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events
by: Erik N. Bergstrom, et al.
Published: (2019-08-01)