Cross-level analysis of molecular and neurobehavioral function in a prospective series of patients with germline heterozygous PTEN mutations with and without autism

Cross-level analysis of molecular and neurobehavioral function in a prospective series of patients with germline heterozygous PTEN mutations with and without autism

Abstract Background PTEN is a well-established risk gene for autism spectrum disorder (ASD). Yet, little is known about how PTEN mutations and associated molecular processes influence neurobehavioral function in mutation carriers with (PTEN-ASD) and without ASD (PTEN no-ASD). The primary aim of the...

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Bibliographic Details
Main Authors: Thomas W. Frazier, Ritika Jaini, Robyn M. Busch, Matthew Wolf, Tammy Sadler, Patricia Klaas, Antonio Y. Hardan, Julian A. Martinez-Agosto, Mustafa Sahin, Charis Eng, the Developmental Synaptopathies Consortium
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Autism
Subjects:
PTEN
Protein
Molecular
Autism spectrum disorder
Cognition
Behavior
Online Access:https://doi.org/10.1186/s13229-020-00406-6

Internet

https://doi.org/10.1186/s13229-020-00406-6

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