Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke

Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke

Stroke is a major cause of mortality and disability worldwide. The main cause of stroke is atherosclerosis, and the most common risk factor for atherosclerosis is hypertension. Therefore, antihypertensive treatments are recommended for the prevention of stroke. Three angiotensin receptor blockers (A...

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Bibliographic Details
Main Authors: Eiichiro Tanaka, Yoshinaka Murai, Ikuro Maruyama, Ko-ichi Kawahara, Naoki Miura, Yoko Morimoto-Yamashita, Salunya Tancharoen, Takashi Ito, Kiyoshi Kikuchi
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:International Journal of Molecular Sciences
Subjects:
stroke
telmisartan
irbesartan
candesartan
high mobility group box 1
receptor for advanced glycation end-products
Online Access:http://www.mdpi.com/1422-0067/14/9/18899

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http://www.mdpi.com/1422-0067/14/9/18899

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