Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found that inserting an enhancer containing pioneer transcription facto...

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Bibliographic Details
Main Authors: Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak, Brian Gebelein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
Notch signaling
Cdk8-Kinase module
enhancer
transcription factor binding sites
degradation
haploinsufficiency
Online Access:https://elifesciences.org/articles/53659

Internet

https://elifesciences.org/articles/53659

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