TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Abstract Background Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer’s Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the multifaceted roles of TREM2 in regulating ext...

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Bibliographic Details
Main Authors: Shane M. Bemiller, Tyler J. McCray, Kevin Allan, Shane V. Formica, Guixiang Xu, Gina Wilson, Olga N. Kokiko-Cochran, Samuel D. Crish, Cristian A. Lasagna-Reeves, Richard M. Ransohoff, Gary E. Landreth, Bruce T. Lamb
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Molecular Neurodegeneration
Subjects:
TREM2
Tauopathy
Alzheimers disease
Inflammation
Immunity
Online Access:http://link.springer.com/article/10.1186/s13024-017-0216-6

Internet

http://link.springer.com/article/10.1186/s13024-017-0216-6

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