A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma

A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma

Ornithine decarboxylase (ODC1), a critical regulatory enzyme in polyamine biosynthesis, is a direct transcriptional target of MYCN, amplification of which is a powerful marker of aggressive neuroblastoma. A single nucleotide polymorphism (SNP), G316A, within the first intron of <i>ODC1</i&g...

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Bibliographic Details
Main Authors: Laura D. Gamble, Stefania Purgato, Michelle J. Henderson, Simone Di Giacomo, Amanda J. Russell, Paolo Pigini, Jayne Murray, Emanuele Valli, Giorgio Milazzo, Federico M. Giorgi, Mark Cowley, Lesley J. Ashton, Jaydutt Bhalshankar, Gudrun Schleiermacher, Ali Rihani, Tom Van Maerken, Jo Vandesompele, Frank Speleman, Rogier Versteeg, Jan Koster, Angelika Eggert, Rosa Noguera, Raymond L. Stallings, Gian Paolo Tonini, Kwun Fong, Zalman Vaksman, Sharon J. Diskin, John M. Maris, Wendy B. London, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Giovanni Perini, Murray D. Norris, Michelle Haber
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
ODC1
MYCN
SNP
neuroblastoma
Online Access:https://www.mdpi.com/2072-6694/13/8/1807

Internet

https://www.mdpi.com/2072-6694/13/8/1807

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