Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Abstract Background Neuronal Ca2+ dyshomeostasis and hyperactivity play a central role in Alzheimer’s disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer’s disease contributes to increased Ca2+ influx and aberrant neuronal activity, which accelerates n...

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Bibliographic Details
Main Authors: Michael Dumbacher, Tom Van Dooren, Katrien Princen, Koen De Witte, Mélissa Farinelli, Sam Lievens, Jan Tavernier, Wim Dehaen, Stefaan Wera, Joris Winderickx, Sara Allasia, Amuri Kilonda, Stéphane Spieser, Arnaud Marchand, Patrick Chaltin, Casper C. Hoogenraad, Gerard Griffioen
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Hyperexcitability
Neuroprotection
Pde6δ
Rap1
Online Access:http://link.springer.com/article/10.1186/s13024-018-0283-3

Internet

http://link.springer.com/article/10.1186/s13024-018-0283-3

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