Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN‐null triple negative breast cancer

Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN‐null triple negative breast cancer

Abstract Triple‐negative breast cancer (TNBC) has poorer prognosis compared to other types of breast cancers due to the lack of effective therapies and markers for patient stratification. Loss of PTEN tumor suppressor gene expression is a frequent event in TNBC, resulting in over‐activation of the P...

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Bibliographic Details
Main Authors: Davide Zecchin, Christopher Moore, Fanourios Michailidis, Stuart Horswell, Sareena Rana, Michael Howell, Julian Downward
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:EMBO Molecular Medicine
Subjects:
G protein
p110β
PTEN
resistance
triple‐negative breast cancer
Online Access:https://doi.org/10.15252/emmm.202011987

Internet

https://doi.org/10.15252/emmm.202011987

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