Epigenomics and genotype-phenotype association analyses reveal conserved genetic architecture of complex traits in cattle and human

Epigenomics and genotype-phenotype association analyses reveal conserved genetic architecture of complex traits in cattle and human

Abstract Background Lack of comprehensive functional annotations across a wide range of tissues and cell types severely hinders the biological interpretations of phenotypic variation, adaptive evolution, and domestication in livestock. Here we used a combination of comparative epigenomics, genome-wi...

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Bibliographic Details
Main Authors: Shuli Liu, Ying Yu, Shengli Zhang, John B. Cole, Albert Tenesa, Ting Wang, Tara G. McDaneld, Li Ma, George E. Liu, Lingzhao Fang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Biology
Subjects:
Comparative epigenomics
GWAS enrichment
Trait-relevant tissues
Human-cattle comparison
Online Access:http://link.springer.com/article/10.1186/s12915-020-00792-6

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http://link.springer.com/article/10.1186/s12915-020-00792-6

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