Estrogens Counteract Platinum-Chemosensitivity by Modifying the Subcellular Localization of MDM4

Estrogens Counteract Platinum-Chemosensitivity by Modifying the Subcellular Localization of MDM4

Estrogen activity towards cancer-related pathways can impact therapeutic intervention. Recent omics data suggest possible crosstalk between estrogens/gender and MDM4, a key regulator of p53. Since MDM4 can either promote cell transformation or enhance DNA damage-sensitivity, we analysed in vivo impa...

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Bibliographic Details
Main Authors: Rossella Lucà, Giorgia di Blasio, Daniela Gallo, Valentina Monteleone, Isabella Manni, Laura Fici, Marianna Buttarelli, Germana Ciolli, Marsha Pellegrino, Emanuela Teveroni, Silvia Maiullari, Alessandra Ciucci, Alessandro Apollo, Francesca Mancini, Maria Pia Gentileschi, Gian Franco Zannoni, Alfredo Pontecorvi, Giovanni Scambia, Fabiola Moretti
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
estrogen
chemosensitivity
MDM4
sexual dimorphism
intracellular trafficking
Online Access:https://www.mdpi.com/2072-6694/11/9/1349

Internet

https://www.mdpi.com/2072-6694/11/9/1349

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