Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition?

Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition?

We report the case of a young woman who developed, 3 years after stopping Rituximab (RTX) prescribed for immune thrombocytopenia (ITP), a severe immunodeficiency leading to fatal pulmonary Epstein–Barr virus-positive diffuse large B-cell lymphoma. Genetic analysis led us to identify four missense mu...

Full description

Bibliographic Details
Main Authors:	Jean-François Viallard, Marie Parrens, Frédéric Rieux-Laucat
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Case Reports in Immunology
Online Access:	http://dx.doi.org/10.1155/2019/2543038

Similar Items

Late-onset hypogammaglobulinemia after rituximab therapy
by: O V Moskalets
Published: (2019-12-01)

Rituximab Associated Hypogammaglobulinemia in Autoimmune Disease
by: Joanna Tieu, et al.
Published: (2021-05-01)

Hypogammaglobulinemia Observed One Year after Rituximab Treatment for Idiopathic Thrombocytopenic Purpura
by: Bilal Ahmad Shoukat, et al.
Published: (2018-01-01)

Antigenic Mimicry in Paraneoplastic Immune Thrombocytopenia
by: Guillaume Vial, et al.
Published: (2019-03-01)

Rituximab-associated Hypogammaglobulinemia in pediatric patients with autoimmune diseases
by: Amer M. Khojah, et al.
Published: (2019-08-01)

Rituximab for children with immune thrombocytopenia: a systematic review.
by: Yi Liang, et al.
Published: (2012-01-01)

Response to rituximab in children and adults with immune thrombocytopenia (ITP)
by: Emily M. Harris, et al.
Published: (2021-08-01)

Sustained drug-free remission and persistent hypogammaglobulinemia in a patient with rheumatoid arthritis three years after discontinuing Rituximab treatment
by: Marco Krasselt, et al.
Published: (2021-04-01)

Rituximab Leads to Long Remissions in Patients with Chronic Immune Thrombocytopenia
by: Khalid Al-Habsi, et al.
Published: (2015-03-01)

Hypogammaglobulinemia sprue
by: A I Parfenov, et al.
Published: (2003-11-01)

Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab
by: Emilio Besada
Published: (2016-01-01)

Rituximab Prevents Stroke Recurrences in Atypical Chronic Immune-Mediated Thrombotic Thrombocytopenic Purpura
by: Henry Dupuy, et al.
Published: (2018-10-01)

Hypogammaglobulinemia with facial edema.
by: Adina Kay Knight, et al.
Published: (2006-12-01)

Cost-per-responder analysis for eltrombopag and rituximab in the treatment of primary immune thrombocytopenia in Spain
by: Eduardo Anguita, et al.
Published: (2020-11-01)

The genetic landscape of the FAS pathway deficiencies
by: Aude Magerus, et al.
Published: (2021-08-01)

A Prospective Observational Study of Hypogammaglobulinemia in the First Year After Lung Transplantation
by: Andrej A. Petrov, MD, et al.
Published: (2018-08-01)

Fatal Chronic Immune Thrombocytopenia with Co-existent Type-1 Neurofibromatosis
by: Daisy Khera, et al.
Published: (2021-05-01)

Tonsillar granuloma associated with hypogammaglobulinemia
by: Aleksi Laajala, et al.
Published: (2020-05-01)

Angioedema as initial manifestation of hypogammaglobulinemia
by: Eunice Giselle López-Rocha, et al.
Published: (2017-06-01)

Symptomatic hypogammaglobulinemia in infancy and childhood – clinical outcome and in vitro immune responses
by: Stein Michael, et al.
Published: (2004-10-01)

Rituximab therapy in a patient with autoimmune hemolytic anemia and immune thrombocytopenia associated with chronic lymphocytic leukemia
by: Aleem Aamer
Published: (2008-01-01)

RASopathies: From germline mutations to somatic and multigenic diseases
by: Quentin Riller, et al.
Published: (2021-08-01)

Otological Findings in Pediatric Patients with Hypogammaglobulinemia
by: Marzieh Tavakol, et al.
Published: (2014-06-01)

Common variable hypogammaglobulinemia: The author's observation
by: A I Parfenov, et al.
Published: (2015-01-01)

Hypogammaglobulinemia in a Family with Crohn’s Disease
by: Robert Enns, et al.
Published: (1996-01-01)

Immunoglobulin replacement therapy in secondary hypogammaglobulinemia
by: Nicolò eCompagno, et al.
Published: (2014-12-01)

Efficacy and Safety of the Combination Treatment of Rituximab and Dexamethasone for Adults with Primary Immune Thrombocytopenia (ITP): A Meta-Analysis
by: Jia Wang, et al.
Published: (2018-01-01)

Steroid-resistant autoimmune thrombocytopenia in systemic lupus erythematosus treated with rituximab
by: Vasudha V Sardesai, et al.
Published: (2015-01-01)

Diagnostic Immunization with Bacteriophage ΦX 174 in Patients with Common Variable Immunodeficiency/Hypogammaglobulinemia
by: Lauren L Smith, et al.
Published: (2014-08-01)

Hypogammaglobulinemia and Risk of Exacerbation and Mortality in Patients with COPD
by: Holm AM, et al.
Published: (2020-04-01)

Mild Hypogammaglobulinemia Can Be a Serious Condition
by: Lisanne M. A. Janssen, et al.
Published: (2018-10-01)

An elderly man with congenital hypogammaglobulinemia and persistent cough
by: Mario Francesco Cannavò, et al.
Published: (2019-04-01)

Primary acquired hypogammaglobulinemia (a case report).
by: Agarwal M, et al.
Published: (1981-04-01)

B cell aplasia and hypogammaglobulinemia associated with levetiracetam
by: Hulya Ozdemir, et al.
Published: (2018-01-01)

Immune Thrombocytopenia Revealing Enriched IgG-4 Peri-Renal Rosai-Dorfman Disease Successfully Treated with Rituximab: A Case Report and Literature Review.
by: Jerome Razanamahery, et al.
Published: (2021-06-01)

Fatal Case of Enterovirus 71 Infection and Rituximab Therapy, France, 2012
by: Somar Kassab, et al.
Published: (2013-08-01)

Total absence of the pericardium associated with hypogammaglobulinemia and bronchiectasis in a girl
by: Rachel Kinuani, et al.
Published: (2019-12-01)

Fatal Cytomegalovirus Disease after Combination Therapy with Corticosteroids and Rituximab for Granulomatosis with Polyangiitis
by: Talal Hilal
Published: (2015-01-01)

Rituximab treatment efficacy in a patient with systemic lupus erythematosus with severe thrombocytopenia
by: Alexandrova O.L., et al.
Published: (2018-09-01)

The role of immunity and neuroinflammation in genetic predisposition and pathogenesis of Alzheimer's disease
by: Seoyoung Yoon, et al.
Published: (2015-09-01)