Activation of AMPK by bitter melon triterpenoids involves CaMKKβ.

Activation of AMPK by bitter melon triterpenoids involves CaMKKβ.

We recently showed that bitter melon-derived triterpenoids (BMTs) activate AMPK and increase GLUT4 translocation to the plasma membrane in vitro, and improve glucose disposal in insulin resistant models in vivo. Here we interrogated the mechanism by which these novel compounds activate AMPK, a leadi...

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Bibliographic Details
Main Authors: Tristan J Iseli, Nigel Turner, Xiao-Yi Zeng, Gregory J Cooney, Edward W Kraegen, Sheng Yao, Yang Ye, David E James, Ji-Ming Ye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3636144?pdf=render

Internet

http://europepmc.org/articles/PMC3636144?pdf=render

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