TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation

TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation

High levels of the inflammatory cytokine tumor necrosis factor-α (TNF-α) are present in atherosclerotic lesions. TNF-α regulates expression of multiple genes involved in various stages of atherosclerosis, and it exhibits proatherosclerotic and antiatherosclerotic properties. ACAT catalyzes the forma...

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Bibliographic Details
Main Authors: Lei Lei, Ying Xiong, Jia Chen, Jin-Bo Yang, Yi Wang, Xin-Ying Yang, Catherine C.Y. Chang, Bao-Liang Song, Ta-Yuan Chang, Bo-Liang Li
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
cholesterol esterification
inflammatory cytokine
lipid metabolism
transcription control
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752030804X

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http://www.sciencedirect.com/science/article/pii/S002222752030804X

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