CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.

CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.

Hypermethylation of CpG islands is a common epigenetic alteration associated with cancer. Global patterns of hypermethylation are tumor-type specific and nonrandom. The biological significance and the underlying mechanisms of tumor-specific aberrant promoter methylation remain unclear, but some evid...

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Bibliographic Details
Main Authors: Rene Opavsky, Shu-Huei Wang, Prashant Trikha, Aparna Raval, Yuan Huang, Yue-Zhong Wu, Benjamin Rodriguez, Benjamin Keller, Sandya Liyanarachchi, Guo Wei, Ramana V Davuluri, Michael Weinstein, Dean Felsher, Michael Ostrowski, Gustavo Leone, Christoph Plass
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1994712?pdf=render

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