Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir.

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir.

The major obstacle to curing HIV infection is the persistence of cells with intact proviruses that can produce replication-competent virus. This HIV reservoir is believed to exist primarily in CD4+ T-cells and is stable despite years of suppressive antiretroviral therapy. A potential mechanism for H...

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Bibliographic Details
Main Authors: John K Bui, Michele D Sobolewski, Brandon F Keele, Jonathan Spindler, Andrew Musick, Ann Wiegand, Brian T Luke, Wei Shao, Stephen H Hughes, John M Coffin, Mary F Kearney, John W Mellors
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006283

Internet

https://doi.org/10.1371/journal.ppat.1006283

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