Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1

Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1

The innate immune protein Stimulator of interferon genes (STING) promotes the induction of interferon beta (IFN-β) production via the phosphorylation of its C-terminal tail (CTT) by TANK-binding kinase 1 (TBK1). Potent ligands of STING are, therefore, promising candidates for novel anti-cancer drugs...

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Bibliographic Details
Main Authors: Yuko Tsuchiya, Nao Jounai, Fumihiko Takeshita, Ken J. Ishii, Kenji Mizuguchi
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:EBioMedicine
Subjects:
STING C-terminal tail
Molecular dynamics simulation
Type I IFNs
TBK1
cGAMP.
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416302419

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http://www.sciencedirect.com/science/article/pii/S2352396416302419

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