The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors

The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors

Hematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional programs that underlie the dynamic progression towards mature lymphoc...

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Bibliographic Details
Main Authors: Veronica Della Chiara, Lucia Daxinger, Frank J. T. Staal
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
T cell development
T cell commitment
transcription factors
epigenetic regulators
chromatin modifiers
Tcf1
Online Access:https://www.mdpi.com/2073-4409/10/5/1074
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spelling doaj-d8b36957234547feb693ed382687c9e72021-04-30T23:06:24ZengMDPI AGCells2073-44092021-04-01101074107410.3390/cells10051074The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription FactorsVeronica Della Chiara0Lucia Daxinger1Frank J. T. Staal2Department of Human Genetics, Leiden University Medical Centre (LUMC), 2300 RC Leiden, The NetherlandsDepartment of Human Genetics, Leiden University Medical Centre (LUMC), 2300 RC Leiden, The NetherlandsDepartment of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsHematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional programs that underlie the dynamic progression towards mature lymphocytes. Lineage-specific transcription factors are key drivers of T cell specification and act in conjunction with epigenetic regulators that have also been elucidated as crucial players in the establishment of regulatory networks necessary for proper T cell development. In this review, we summarize the activity of transcription factors and epigenetic regulators that together orchestrate the intricacies of early T cell development with a focus on regulation of T cell lineage commitment.https://www.mdpi.com/2073-4409/10/5/1074T cell developmentT cell commitmenttranscription factorsepigenetic regulatorschromatin modifiersTcf1
collection DOAJ
language English
format Article
sources DOAJ
author Veronica Della Chiara
Lucia Daxinger
Frank J. T. Staal
spellingShingle Veronica Della Chiara
Lucia Daxinger
Frank J. T. Staal
The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors
Cells
T cell development
T cell commitment
transcription factors
epigenetic regulators
chromatin modifiers
Tcf1
author_facet Veronica Della Chiara
Lucia Daxinger
Frank J. T. Staal
author_sort Veronica Della Chiara
title The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors
title_short The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors
title_full The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors
title_fullStr The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors
title_full_unstemmed The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors
title_sort route of early t cell development: crosstalk between epigenetic and transcription factors
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2021-04-01
description Hematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional programs that underlie the dynamic progression towards mature lymphocytes. Lineage-specific transcription factors are key drivers of T cell specification and act in conjunction with epigenetic regulators that have also been elucidated as crucial players in the establishment of regulatory networks necessary for proper T cell development. In this review, we summarize the activity of transcription factors and epigenetic regulators that together orchestrate the intricacies of early T cell development with a focus on regulation of T cell lineage commitment.
topic T cell development
T cell commitment
transcription factors
epigenetic regulators
chromatin modifiers
Tcf1
url https://www.mdpi.com/2073-4409/10/5/1074
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