RCAN1 Knockdown Reverts Defects in the Number of Calcium-Induced Exocytotic Events in a Cellular Model of Down Syndrome

RCAN1 Knockdown Reverts Defects in the Number of Calcium-Induced Exocytotic Events in a Cellular Model of Down Syndrome

In humans, Down Syndrome (DS) is a condition caused by partial or full trisomy of chromosome 21. Genes present in the DS critical region can result in excess gene dosage, which at least partially can account for DS phenotype. Although regulator of calcineurin 1 (RCAN1) belongs to this region and its...

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Bibliographic Details
Main Authors: Jacqueline Vásquez-Navarrete, Agustín D. Martínez, Stéphane Ory, Ximena Baéz-Matus, Arlek M. González-Jamett, Sebastián Brauchi, Pablo Caviedes, Ana M. Cárdenas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
down syndrome
exocytosis
cholinergic vesicles
RCAN1
trisomy 16
total internal reflection fluorescence microscopy
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00189/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00189/full

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