Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques

Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques

Abstract Antibody-dependent enhancement (ADE) is suspected to influence dengue virus (DENV) infection, but the role ADE plays in vaccination strategies incorporating live attenuated virus components is less clear. Using a heterologous prime-boost strategy in rhesus macaques, we examine the effect of...

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Bibliographic Details
Main Authors: Michael K. McCracken, Caitlin H. Kuklis, Chandrika B. Kannadka, David A. Barvir, Mark A. Sanborn, Adam T. Waickman, Hayden C. Siegfried, Kaitlin A. Victor, Kristin L. Hatch, Rafael De La Barrera, Shannon D. Walls, Wiriya Rutvisuttinunt, Jeffrey R. Currier, Heather Friberg, Richard G. Jarman, Gregory D. Gromowski
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00339-y

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https://doi.org/10.1038/s41541-021-00339-y

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