Dynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by Thrombin.

Dynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by Thrombin.

Biomolecular recognition is crucial in cellular signal transduction. Signaling is mediated through molecular interactions at protein-protein interfaces. Still, specificity and promiscuity of protein-protein interfaces cannot be explained using simplistic static binding models. Our study rationalizes...

Full description

Bibliographic Details
Main Authors: Julian E Fuchs, Roland G Huber, Birgit J Waldner, Ursula Kahler, Susanne von Grafenstein, Christian Kramer, Klaus R Liedl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4619833?pdf=render

Internet

http://europepmc.org/articles/PMC4619833?pdf=render

Similar Items