LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

Abstract Mutations in leucine-rich repeat kinase 2 (LRRK2) are one of the most common causes of familial Parkinson’s disease (PD). The most common mutations in the LRRK2 gene induce elevated kinase activity of the LRRK2 protein. Recent studies have also suggested that LRRK2 kinase activity may be el...

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Bibliographic Details
Main Authors: Michael X. Henderson, Medha Sengupta, Ian McGeary, Bin Zhang, Modupe F. Olufemi, Hannah Brown, John Q. Trojanowski, Virginia M. Y. Lee
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Acta Neuropathologica Communications
Subjects:
Leucine-rich repeat kinase 2
pS129
Aggregation
Inhibitor
G2019S
MLi-2
Online Access:http://link.springer.com/article/10.1186/s40478-019-0679-5

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http://link.springer.com/article/10.1186/s40478-019-0679-5

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