Pirfenidone Inhibits Cell Proliferation and Collagen I Production of Primary Human Intestinal Fibroblasts

Pirfenidone Inhibits Cell Proliferation and Collagen I Production of Primary Human Intestinal Fibroblasts

Intestinal fibrosis is a common complication of inflammatory bowel disease. So far, there is no safe and effective drug for intestinal fibrosis. Pirfenidone is an anti-fibrotic compound available for the treatment of idiopathic pulmonary fibrosis. Here, we explored the anti-proliferative and anti-fi...

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Bibliographic Details
Main Authors: Yingying Cui, Mengfan Zhang, Changsen Leng, Tjasso Blokzijl, Bernadien H. Jansen, Gerard Dijkstra, Klaas Nico Faber
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
intestinal fibrosis
pirfenidone
mtor
tgf-β1
collagen
fibroblast
inflammatory bowel disease
Online Access:https://www.mdpi.com/2073-4409/9/3/775

Internet

https://www.mdpi.com/2073-4409/9/3/775

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