Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging

Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging

Abstract Chronic obstructive pulmonary disease (COPD) has been recently characterized as a disease of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged as key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice w...

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Main Authors: Yingji Jin, Yoshito Takeda, Yasushi Kondo, Lokesh P. Tripathi, Sujin Kang, Hikari Takeshita, Hanako Kuhara, Yohei Maeda, Masayoshi Higashiguchi, Kotaro Miyake, Osamu Morimura, Taro Koba, Yoshitomo Hayama, Shohei Koyama, Kaori Nakanishi, Takeo Iwasaki, Satoshi Tetsumoto, Kazuyuki Tsujino, Muneyoshi Kuroyama, Kota Iwahori, Haruhiko Hirata, Takayuki Takimoto, Mayumi Suzuki, Izumi Nagatomo, Ken Sugimoto, Yuta Fujii, Hiroshi Kida, Kenji Mizuguchi, Mari Ito, Takashi Kijima, Hiromi Rakugi, Eisuke Mekada, Isao Tachibana, Atsushi Kumanogoh
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-23338-x

Internet

https://doi.org/10.1038/s41598-018-23338-x

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