Mechanism of Action of Methotrexate Against Zika Virus

Mechanism of Action of Methotrexate Against Zika Virus

Zika virus (ZIKV), which is associated with microcephaly in infants and Guillain-Barré syndrome, reemerged as a serious public health threat in Latin America in recent years. Previous high-throughput screening (HTS) campaigns have revealed several potential hit molecules against ZIKV, inclu...

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Bibliographic Details
Main Authors: Sungjun Beck, Zhe Zhu, Michelli F. Oliveira, Davey M. Smith, Jeremy N. Rich, Jean A. Bernatchez, Jair L. Siqueira-Neto
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Viruses
Subjects:
Zika virus
antivirals
nucleotide metabolism
methotrexate
dihydrofolate reductase
Online Access:https://www.mdpi.com/1999-4915/11/4/338

Internet

https://www.mdpi.com/1999-4915/11/4/338

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