Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer.

Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer.

Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among solid malignancies and improved therapeutic strategies are needed to improve outcomes. Patient-derived xenografts (PDX) and patient-derived organoids (PDO) serve as promising tools to identify new drugs with therapeutic potential...

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Bibliographic Details
Main Authors: Deena M A Gendoo, Robert E Denroche, Amy Zhang, Nikolina Radulovich, Gun Ho Jang, Mathieu Lemire, Sandra Fischer, Dianne Chadwick, Ilinca M Lungu, Emin Ibrahimov, Ping-Jiang Cao, Lincoln D Stein, Julie M Wilson, John M S Bartlett, Ming-Sound Tsao, Neesha Dhani, David Hedley, Steven Gallinger, Benjamin Haibe-Kains
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1006596

Internet

https://doi.org/10.1371/journal.pcbi.1006596

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