Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.

by Lisa Leung, Nikolina Radulovich, Chang-Qi Zhu, Dennis Wang, Christine To, Emin Ibrahimov, Ming-Sound Tsao
Published 2013-01-01

Lipocalin2 promotes invasion, tumorigenicity and gemcitabine resistance in pancreatic ductal adenocarcinoma.

by Lisa Leung, Nikolina Radulovich, Chang-Qi Zhu, Shawna Organ, Bizhan Bandarchi, Melania Pintilie, Christine To, Devang Panchal, Ming Sound Tsao
Published 2012-01-01

Stability and Heterogeneity of Expression Profiles in Lung Cancer Specimens Harvested Following Surgical Resection

by Fiona H. Blackhall, Melania Pintilie, Dennis A. Wigle, Igor Jurisica, Ni Liu, Nikolina Radulovich, Michael R. Johnston, Shaf Keshavjee, Ming-Sound Tsao
Published 2004-11-01

p120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line.

by Shawna L Organ, Josephine Hai, Nikolina Radulovich, Christopher B Marshall, Lisa Leung, Takehiko Sasazuki, Senji Shirasawa, Chang-Qi Zhu, Roya Navab, Mitsuhiko Ikura, Ming-Sound Tsao
Published 2014-01-01

Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer.

by Deena M A Gendoo, Robert E Denroche, Amy Zhang, Nikolina Radulovich, Gun Ho Jang, Mathieu Lemire, Sandra Fischer, Dianne Chadwick, Ilinca M Lungu, Emin Ibrahimov, Ping-Jiang Cao, Lincoln D Stein, Julie M Wilson, John M S Bartlett, Ming-Sound Tsao, Neesha Dhani, David Hedley, Steven Gallinger, Benjamin Haibe-Kains
Published 2019-01-01

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

by Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Nikolina Radulovich, Betty P. K. Poon, Jonathan St-Germain, Jonathan D. Cook, Ivette Valencia-Sama, Benjamin M. M. Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S. Irwin, Jeffrey E. Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh
Published 2019-01-01

Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers

by Nhu-An Pham, Nikolina Radulovich, Emin Ibrahimov, Sebastiao N. Martins-Filho, Quan Li, Melania Pintilie, Jessica Weiss, Vibha Raghavan, Michael Cabanero, Robert E. Denroche, Julie M. Wilson, Cristiane Metran-Nascente, Ayelet Borgida, Shawn Hutchinson, Anna Dodd, Michael Begora, Dianne Chadwick, Stefano Serra, Jennifer J. Knox, Steven Gallinger, David W. Hedley, Lakshmi Muthuswamy, Ming-Sound Tsao
Published 2021-05-01