Quercetin improves the impairment in memory function and attenuates hippocampal damage in cadmium chloride-intoxicated male rats by suppressing acetylcholinesterase and concomitant activation of SIRT1 signaling

Quercetin improves the impairment in memory function and attenuates hippocampal damage in cadmium chloride-intoxicated male rats by suppressing acetylcholinesterase and concomitant activation of SIRT1 signaling

This study examined if quercetin (QUR) prevents cadmium chloride (CdCl2)-induced hippocampal neurotoxicity in male rats by activating sirtuin-1 (SIRT1). Rats were divided into control, control + QUR, CdCl2, CdCl2 + QUR, and CdCl2 + QUR + EX-527 (a SIRT1 inhibitor). QUR (25 mg/kg) and CdCl2 (0.5 mg/k...

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Bibliographic Details
Main Authors: Ghedeir M. Alshammari, Wahidah H. Al-Qahtani, Mohammad A. Alshuniaber, Abu ElGasim A. Yagoub, Abdullrahman S. Al-Khalifah, Laila Naif Al-Harbi, Maha H. Alhussain, Sahar Abdulaziz AlSedairy, Mohammed Abdo Yahya
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Journal of Functional Foods
Subjects:
Quercetin
Hippocampus
CdCl2
Memory
Acetylcholine
SIRT1
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621003248

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http://www.sciencedirect.com/science/article/pii/S1756464621003248

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