Fractalkine Modulates Microglia Metabolism in Brain Ischemia

Fractalkine Modulates Microglia Metabolism in Brain Ischemia

In the CNS, the chemokine CX3CL1 (fractalkine) is expressed on neurons while its specific receptor CX3CR1 is expressed on microglia and macrophages. Microglia play an important role in health and disease through CX3CL1/CX3CR1 signaling, and in many neurodegenerative disorders, microglia dysregulatio...

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Bibliographic Details
Main Authors: Clotilde Lauro, Giuseppina Chece, Lucia Monaco, Fabrizio Antonangeli, Giovanna Peruzzi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Cristina Limatola
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CX3CL1
microglia
ischemia
neuroprotection
neuroinflammation
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00414/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00414/full

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