Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors

Fatty Acid Amide Hydrolase (FAAH) is a serine hydrolase that plays a key role in controlling endogenous levels of endocannabinoids. FAAH inhibition is considered a powerful approach to enhance the endocannabinoid signalling, and therefore it has been largely studied as a potential target for the tre...

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Bibliographic Details
Main Authors: Alessandro Deplano, Mariateresa Cipriano, Federica Moraca, Ettore Novellino, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
ibuprofen amides
faah inhibition
fatty acid amide hydrolase
endocannabinoids
induced fit docking
Online Access:http://dx.doi.org/10.1080/14756366.2018.1532418

Internet

http://dx.doi.org/10.1080/14756366.2018.1532418

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