Identification of Inhibitors to <i>Trypanosoma cruzi</i> Sirtuins Based on Compounds Developed to Human Enzymes

Identification of Inhibitors to <i>Trypanosoma cruzi</i> Sirtuins Based on Compounds Developed to Human Enzymes

Chagas disease is an illness caused by the protozoan parasite <i>Trypanosoma cruzi</i>, affecting more than 7 million people in the world. Benznidazole and nifurtimox are the only drugs available for treatment and in addition to causing several side effects, are only satisfactory in the...

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Bibliographic Details
Main Authors: Tanira Matutino Bastos, Milena Botelho Pereira Soares, Caio Haddad Franco, Laura Alcântara, Lorenzo Antonini, Manuela Sabatino, Nicola Mautone, Lucio Holanda Freitas-Junior, Carolina Borsoi Moraes, Rino Ragno, Dante Rotili, Sergio Schenkman, Antonello Mai, Nilmar Silvio Moretti
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
sirtuins
<i>Trypanosoma cruzi</i>
sirtuin inhibitors
deacetylation
Online Access:https://www.mdpi.com/1422-0067/21/10/3659

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https://www.mdpi.com/1422-0067/21/10/3659

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