Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

by Caio Haddad Franco, Laura Maria Alcântara, Eric Chatelain, Lucio Freitas-Junior, Carolina Borsoi Moraes
Published 2019-05-01

An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite Trypanosoma cruzi.

by Seunghyun Moon, Jair L Siqueira-Neto, Carolina Borsoi Moraes, Gyongseon Yang, Myungjoo Kang, Lucio H Freitas-Junior, Michael A E Hansen
Published 2014-01-01

Identification of Inhibitors to <i>Trypanosoma cruzi</i> Sirtuins Based on Compounds Developed to Human Enzymes

by Tanira Matutino Bastos, Milena Botelho Pereira Soares, Caio Haddad Franco, Laura Alcântara, Lorenzo Antonini, Manuela Sabatino, Nicola Mautone, Lucio Holanda Freitas-Junior, Carolina Borsoi Moraes, Rino Ragno, Dante Rotili, Sergio Schenkman, Antonello Mai, Nilmar Silvio Moretti
Published 2020-05-01

Amazonian Plant Natural Products: Perspectives for Discovery of New Antimalarial Drug Leads

by Lucio H. Freitas-Junior, Pedro Cravo, Marcus Vinícius Guimarães Lacerda, André Machado Siqueira, Carolina Borsoi Moraes, Gina Frausin, Luiz Francisco Rocha e Silva, Stefanie Costa Pinto Lopes, Renata Braga Souza Lima, Fabio Trindade Maranhão Costa, Adrian Martin Pohlit
Published 2013-08-01

An essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway.

by Mariana Serpeloni, Carolina Borsoi Moraes, João Renato Carvalho Muniz, Maria Cristina Machado Motta, Augusto Savio Peixoto Ramos, Rafael Luis Kessler, Alexandre Haruo Inoue, Wanderson Duarte daRocha, Sueli Fumie Yamada-Ogatta, Stenio Perdigão Fragoso, Samuel Goldenberg, Lucio H Freitas-Junior, Andréa Rodrigues Avila
Published 2011-01-01

Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, <i>Boana raniceps</i>

by Carlos José Correia Santana, Ana Carolina Martins Magalhães, César Augusto Prías-Márquez, Diego A. Falico, Agenor C. M. dos Santos Júnior, Beatriz D. Lima, Carlos André Ornelas Ricart, Denise Regina Bairros de Pilger, Rafaela Milan Bonotto, Carolina Borsoi Moraes, Lúcio H. Freitas-Júnior, Alice da Cunha Morales Álvares, Sonia Maria Freitas, Isabelle S. Luz, Osmindo Rodrigues Pires Jr., Wagner Fontes, Mariana S. Castro
Published 2020-05-01

Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study.

by Jose Xavier-Neto, Murilo Carvalho, Bruno Dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, Kleber Franchini
Published 2017-02-01